Peptide/protein vaccine delivery system based on PLGA particles

Vaccine delivery system for tuberculosis based on nano-sized hepatitis B virus core protein particles

Nano-sized hepatitis B virus core virus-like particles (HBc-VLP) are suitable for uptake by antigen-presenting cells. Mycobacterium tuberculosis antigen culture filtrate protein 10 (CFP-10) is an important vaccine candidate against tuberculosis. The purified antigen shows low immune response without adjuvant and tends to have low protective efficacy. The present study is based on the assumption...

recombinant sag1 antigen - loaded plga microspheres as a novel vaccine delivery system against toxoplasma gondii

Biodegradable particles as vaccine delivery systems

ii AKNOWLEDGEMENTS I would like to extend heartfelt gratitude to my teachers, colleagues and friends for their support and help that has brought this thesis research to a successful completion. I am deeply indebted to my supervisor Dr. Aliasger Salem for giving me the grand opportunity to undertake this thesis research. His awe-inspiring personality, stimulating suggestions and encouragement ha...

Chitosan-based Nanoparticles in Mucosal Vaccine Delivery

Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. V...

Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system

The study investigated the reversal of multidrug resistance (MDR) and the biodistribution of nanoparticles (NPs) that target leukemia cells in a nude mice model via a surface-bound transferrin (Tf). The cytotoxic cargo of daunorubicin (DNR) and tetrandrine (Tet) was protected in the NPs by an outer coat composed of polyethylene glycol (PEG)-poly-L-lysine (PLL)-poly(lactic-co-glycolic acid) (PLG...